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Bayesian Adaptive Trials: Perth 2019

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Join us for intensive workshops where you will take away the knowledge and practical skills that are fundamental for designing Bayesian adaptive clinical trials. The first workshop looks at simple adaptive trial designs and is suitable for both statisticians and non-statisticians. You will get hands-on experience of a simple trial simulator using functions that have been specially written for the course, so you don’t need to be an expert in programming in R (https://www.r-project.org/).   The second workshop looks at more complex adaptive trial designs and is suitable for statisticians and other researchers who are proficient in statistical inference, modelling, and clinical trial design. 

We are thrilled to welcome Bayesian clinical trial experts Ben Saville, PhD & Anna McGlothlin, PhD from Berry Consultants USA (https://www.berryconsultants.com/), and Mark Jones, MSc & Julie Marsh, PhD from Telethon Kids Institute (https://adaptivehealthintelligence.org.au/). This event will be held at the Telethon Kids Institute, Perth , Australia and is organised by the Adaptive Health Intelligence team. It is supported by funding from the Channel 7 Telethon Trust, and the Australian Clinical Trials Alliance. Staff and students of Telethon Kids Institute and Perth Children's Hospital are eligible for discounted rates (ID badge to be sighted on the day).


Workshop 1: December 4 - Simple adaptive designs

Topics include simple group sequential adaptive designs for binary, continuous, and time to event endpoints, multiple interim analyses evaluating efficacy and safety, Bayesian decision criteria for futility and success, and a general overview of Bayesian methodology for clinical trials. We teach these methods using real clinical trial examples and show the utility of simulations in navigating funding and regulatory environments. We encourage individual participation with breakout sessions, in which attendees meet in small groups to explore Bayesian strategies for simple case studies.

Target audience: clinicians, statisticians, data scientists, reviewers of health funding applications, human research ethics committee members and data safety & monitoring board members with a good working knowledge of clinical trials and some familiarity with statistical hypothesis testing. Little knowledge of R software will be assumed as R functions will be provided to explore the design concepts and parameters.


Workshop 2: December 5 - Complex adaptive designs
Topics include response adaptive randomisation, Bayesian borrowing of external information, Bayesian hierarchical models, including longitudinal models to inform interim decisions, and multi-arm platform trials with a shared control arm. We will demonstrate how Bayesian methods can enable more flexible, efficient, and innovative clinical trial designs. We teach these methods using real clinical trial examples and show the utility of simulations in navigating funding and regulatory environments. We encourage individual participation with interactive breakout sessions illustrating key adaptive trial concepts. 

Target audience: data scientists and other highly numerate researchers with a good knowledge of statistical inference and clinical trial design. A basic knowledge of Bayesian methodology and statistical software is helpful but not required.


 

Location

Telethon Kids Institute
Northern Entrance, 15 Hospital Avenue, Nedlands, WA 6009

Contact Details

Map

 

Cost

Designing simple adaptive trials [Full Day]: $150

Designing complex adaptive trials [Full Day]: $150

A reduced rate of $50 per day is offered to students or staff from Perth Children’s Hospital or Telethon Kids Institute. This is available through generous sponsorship from the Channel 7 Telethon Trust.