Five years post-Jurassic World Dominion, an expedition braves isolated equatorial regions to extract DNA from three massive prehistoric creatures for a groundbreaking medical breakthrough.

On a forbidden island in the middle of the Atlantic Ocean, named Ile Saint-Hubert, InGen creates a group of transgenic mutated dinosaurs. Unfortunately, one of the creatures, a distorted 6 limbed Pterosaur, which they named Distorus Rex escaped from confinement, in doing so, causing the lab to be evacuated.

17 years into the future, Earth has become very welcoming to dinosaurs and other once extinct creatures. The reborn creatures now reside in tropical environments, close to the ones they once inhabited. A covert operative named Zora Bennett is called up and hired by Martin Krebs, the head of a pharmaceutical company and he asks her to collaborate with paleontologist Dr. Henry Loomis and the leader of the team, Duncan Kincaid, in planning a trip to Ile Saint-Hubert to retrieve some blood samples of the remaining dinosaurs. It is revealed that the biomaterials of the creatures hold the secret for the cure of coronary heart disease. Within them, a drug.